A study that followed thousands of people over 25 years has identified proteins linked to the development of dementia if their levels are unbalanced during middle age. From a report: The findings, published in Science Translational Medicine on 19 July, could contribute to the development of new diagnostic tests, or even treatments, for dementia-causing diseases. Most of the proteins have functions unrelated to the brain. “We’re seeing so much involvement of the peripheral biology decades before the typical onset of dementia,” says study author Keenan Walker, a neuroscientist at the US National Institute on Aging in Bethesda, Maryland. Equipped with blood samples from more than 10,000 participants, Walker and his colleagues questioned whether they could find predictors of dementia years before its onset by looking at a person’s proteome — the collection of all the proteins expressed throughout the body. They searched for any signs of dysregulation — when proteins are at levels much higher or lower than normal.

The samples were collected as part of an ongoing study that began in 1987. Participants returned for examination six times over three decades, and during this time, around 1 in 5 of them developed dementia. The researchers found 32 proteins that, if dysregulated in people aged 45 to 60, were strongly associated with an elevated chance of developing dementia in later life. It is unclear how exactly these proteins might be involved in the disease, but the link is “highly unlikely to be due to just chance alone,” says Walker.

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Source: Slashdot – Dementia Risk Linked To Blood-Protein Imbalance in Middle Age

Google co-founder Sergey Brin is back at work. The multibillionaire has been visiting the tech giant’s Mountain View, Calif., offices in recent months generally three to four days a week, working alongside researchers as they push to develop the company’s next large artificial-intelligence system. WSJ: Brin participated in meetings about AI at Google’s offices late last year, but the frequency and intensity of his involvement has picked up, said people familiar with the matter. His new stance is a notable change from the relatively hands-off approach he adopted after stepping down from an executive role at parent company Alphabet in 2019.

He has worked closely with a group of researchers building Google’s long-awaited AI model Gemini. They have discussed technical matters such as “loss curves,” a way of measuring an AI program’s performance over time, and Brin has convened weekly discussions of new AI research with Google employees. He also has intervened in personnel matters, such as the hiring of sought-after researchers, the people said. Brin’s increased presence at Google reflects the pivotal moment in AI and his longstanding interest in the technology, which Google pioneered but was slower than rivals to turn into new products, said current and former employees.

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Source: Slashdot – Sergey Brin Is Back in the Trenches at Google