UCI backtracks on “hugely discriminatory” handlebar width rule – but reserves the right to change its mind

The UCI has backtracked on parts of its controversial handlebar width proposals.

While the UCI confirmed the proposed 400mm width measurement, the minimum distance between the inner edges of the brake hoods has decreased from the proposed 320mm to 280mm, and there’s a new maximum flare figure of 65mm.

This may go some way to winning round critics of the proposed rule, who claimed the original proposals could disadvantage women and smaller riders, although the UCI has also said the updated rule may be modified in the future.

Additional details have also been revealed about how the sport’s governing body intends to distinguish between ‘road’ and ‘time trial’ helmets.

The UCI U-turns… for now

Julian Alaphilippe's BMC Teammachine SLR 01 at the 2025 Tour de France
Pro handlebars have been getting narrower in recent years, as riders chase aero gains. Ashley Quinlan / Our Media

The proposed handlebar width measurements proposed back in June were widely decried by professional riders and the bike industry alike.

One source told BikeRadar that the new rules were “hugely discriminatory” against women cyclists and smaller riders in general, who would typically currently ride handlebars narrower than 400mm. It would also force some brands to scrap their current road bike bars and develop new designs to conform to the regulations.

The new hood-to-hood measurement of 280mm should ease these objections somewhat, and the UCI said the new measurement follows consultation with “cycling’s stakeholders including representatives of the cycling industry, findings from extensive verifications of current dimensions used for bikes at UCI Women’s WorldTour and UCI WorldTour events”.

The UCI counters that the proposed regulation was aimed at slowing riders down by increasing the drag on riders and bikes, as part of its goal of controlling race speeds, with the objective of improving rider safety. 

There’s already a test of limits on maximum gear ratios slated for this year’s Tour of Guangxi, taking place in October, also aimed at decreasing race speeds.

This has resulted in SRAM filing a complaint against the UCI with the Belgian Competition Authority which has launched anti-trust proceedings against the UCI, as the brand says the trial will “unfairly disadvantage SRAM riders and SRAM”.

Primoz Roglic's Specialized S-Works Tarmac SL8 at the 2025 Tour de France
SRAM recently announced it is taking legal action against the UCI’s proposed maximum gearing test. Simon von Bromley / Our Media

There’s a sting in the tail of the relaxed bar width regs though, with the UCI management committee suggesting that the minimum handlebar width numbers could increase going forward.

It says its management committee has instructed the UCI Equipment and New Technologies Commission to “review” the measurements and consult with stakeholders during the 2026 season, “ with a view to potentially increasing it for future seasons”. 

Track riders fare better, with a minimum 350mm width at the drops, 80mm flare and 65mm cross section for their bars.

Clarification of aero helmet regulations

POC Procen Air and Specilaized Evade 3 aero helmets
The UCI has revealed details of how it will distinguish between TT and road helmets for 2026 and beyond. Simon von Bromley / Our Media

The UCI has also aimed to clarify the new regulation that will distinguish between ‘road’ and ‘time trial’ helmets, as aero road helmets have become steadily more TT helmet-like.

The POC Procen Air helmet worn by the EF Education pro team, for example, encloses the tops of a rider’s ears and there are just three front vents. Victor Campenaerts and his Visma-Lease a Bike teammates have also been wearing the Giro Aerohead MIPS TT helmet, minus its visor, in many mass start road races this season.

It appears both helmets would be banned from January 2026, under the new rules, which stipulate “minimum ventilation requirements, a ban on helmet shells or accessories covering or obstructing the riders’ ears, and a ban on integrated or detachable visors”.

Again, the UCI’s justification is “to contain aerodynamics”, decrease rider speeds and improve safety, as well as to distinguish between helmets used in different disciplines.

    DeepMind’s robotic ballet: An AI for coordinating manufacturing robots

    A lot of the stuff we use today is largely made by robots—arms with multiple degrees of freedom positioned along conveyor belts that move in a spectacle of precisely synchronized motions. All this motion is usually programmed by hand, which can take hundreds to thousands of hours. Google’s DeepMind team has developed an AI system called RoboBallet that lets manufacturing robots figure out what to do on their own.

    Traveling salesmen

    Planning what manufacturing robots should do to get their jobs done efficiently is really hard to automate. You need to solve both task allocation and scheduling—deciding which task should be done by which robot in what order. It’s like the famous traveling salesman problem on steroids. On top of that, there is the question of motion planning; you need to make sure all these robotic arms won’t collide with each other, or with all the gear standing around them.

    At the end, you’re facing a myriad of possible combinations where you’ve got to solve not one but three computationally hard problems at the same time. “There are some tools that let you automate motion planning, but task allocation and scheduling are usually done manually,” says Matthew Lai, a research engineer at Google DeepMind. “Solving all three of these problems combined is what we tackled in our work”.

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    UCI announces price caps for 2028 Olympic track bikes and equipment

    The UCI has announced it will cap the prices of track bikes and equipment used at the 2028 Olympic Games in Los Angeles.

    Following the 2024 Paris Games, which saw the cost of track bikes and related equipment soar to unprecedented levels, cycling’s governing body says price caps will bolster “the integrity of competitions by preventing excessive cost barriers”.

    Though details of exactly how price caps will be implemented – or what level they will be set at – have not been revealed, the UCI says “maximum prices will apply for framesets, forks, wheels, handlebars and their extensions, helmets and skinsuits” from 1 January 2027.

    The UCI says this decision has been approved by its management committee, which is headed by UCI president David Lappartient, and is designed to ensure “participants from all nations have fair access to equipment”.

    Why does the UCI want to cap the prices of track bikes and kit?

    3D-printed aero extension on Hope HB.T Paris
    The cost of many track bikes has ballooned in recent years, and the UCI isn’t happy about it. Scott Windsor / Our Media

    According to the UCI, the establishment of price caps for track bikes and related equipment will complement its existing rules on commercial availability, which are intended to create a more level playing field in terms of access to equipment.

    As before, new bikes and related equipment will need to be registered with the UCI and used in events prior to the Olympics in order to ensure compliance with the rules.

    In theory, this gives competing nations a chance to see – and potentially purchase – any bike or item of equipment, clothing and so on, prior to the Games.

    It seems the spiralling cost of Olympic track bikes and kit may have prompted the UCI to take action against prices that appear to be designed to discourage or even prevent such kit from actually being purchased by rivals.

    The V-IZU TCM2 and TC-M1 track bikes used by the Japanese cycling team, for example, were priced at €126,555 and €112,320, respectively, according to the UCI’s ‘Final Equipment List’.

    The UK Sports Institute UKSI-BC1 track bike, used by Team GB, was listed at €64,350 for a frameset alone, while other bikes from top nations were priced at similarly astronomical levels.

    Hope HB.T Paris track bike
    Wild designs and novel constructions methods have put top track bikes and related equipment out of reach for many. Scott Windsor / Our Media

    And that’s just bikes and framesets. The Pinarello MOST custom 3D-printed bar extensions used by the Italian cycling team were listed at €22,500, while the Black Inc Zero tubular disc wheelset was priced at €18,400.

    In comparison, the most expensive bike listed ahead of the 2020 Tokyo Olympics was the Worx WX-R Vorteq Track, at €28,000.

    With incoming regulation changes potentially banning radical track bikes such as the Hope HB.T and Look P24, it looks as if major cycling nations will need to go back to the drawing board and create bikes that are not only fast, but reasonably priced.

    What counts as ‘reasonable’ according to the UCI remains to be seen, though nations will doubtless be hoping for clarity sooner than later given the limited time scale to develop new bikes and equipment before the next Olympic Games.

    Proton Mail’s redesigned mobile app is built for speed

    If you use Proton Mail on your phone, things are about to pick up. The company is rolling out new apps for Android and iOS. The updated mobile applications are rebuilt from the ground up with a “cleaner, faster and more private experience.” Proton first announced in April that it was working on the revamp.

    The company says the new Proton Mail lets you scroll, archive and reply twice as fast as before. It also now supports an offline mode, allowing you to read, write and organize messages while away from the internet. A redesigned interface aims for simpler navigation, with areas like the composer button now sitting within easier reach.

    The iOS and Android apps, while still native to their respective platforms, now share a common codebase. Proton says they share 80 percent of their code. This should enable faster development and near-simultaneous future updates.

    Two staggered screenshots of the new Proton Mail update's offline mode.
    Proton

    Product lead Anant Vijay Singh credited the update to Proton’s community and business model. “The new Proton Mail mobile apps reflect this feedback and show what is possible if you build an email app without the constraints imposed by trying to monetize user data, allowing for a cleaner, faster, and more private experience,” he said.

    Proton has had a full plate lately. The company is working on an upcoming overhaul of Proton Calendar with similar user experience upgrades. This summer, it even joined the chatbot fracas with Lumo, which it believes can carve a niche as a more ethical AI assistant.

    The Proton Mail updates begin rolling out today in the App Store and Play Store.

    This article originally appeared on Engadget at https://www.engadget.com/mobile/smartphones/proton-mails-redesigned-mobile-app-is-built-for-speed-100042054.html?src=rss

    Japanese City Passes Two-Hours-a-Day Smartphone Usage Ordinance

    The Japanese city of Toyoake has passed (PDF) a symbolic ordinance limiting recreational smartphone use to two hours a day, aiming to improve citizens’ sleep — especially for students after summer vacation. The Register reports: “The primary purpose of this ordinance is to ensure that all citizens receive adequate sleep,” states a Council information page, which explains that many Japanese people ignore Ministry of Health, Labor and Welfare recommendations to spend six to eight hours a day dozing. An accompanying FAQ [PDF] explains that Council passed the ordinance because students who return to school after summer vacations sometimes need a nudge the re-establish an appropriate daily regime.

    The ordinance also points out “Excessive phone users and their families are facing difficulties in their daily and social lives,” and suggests the two-hours-a-day guidance might help. Council’s documents point out that smartphones have myriad uses beyond recreation, and that the ordinance should not be taken as a suggestion to reduce overall use of the devices. Toyoake is part of the Nagoya megalopolis and is home to around 70,000 people. The town’s government plans to survey residents about the ordinance, and the FAQ also mentions it wants to tackle other digital menaces, among them harmful effects of using smartphones while walking.


    Read more of this story at Slashdot.

    British bike brand releases ‘world’s lightest production bike’ at 5.24kg

    The new Black Series Corsa is the lightest production bike in the world, at 5.24kg, according to its designer, Andy Wallis.

    The Black Series range of bikes and components has long been the ’secret’ or ‘special projects’ label of engineer and designer Wallis, the owner of Poshbikes.

    Wallis says: “Whenever a new frame, wheelset or component was required to outperform the standard item, or a specific bicycle is required for a factory race team, when one was not available from their current line-up, a custom item was created under the Black Series codename.”

    Over the years, this special project division has amassed a collection of frames and components that have proven themselves for pro riders. Yet they’ve never been available to the public, until now.

    Wallis is readying a complete line-up of Black Series bikes and components, including road, aero, gravel and hardtail XC mountain bikes. There are also bars, stems, seatposts, wheels, hubs and a host of small parts, all under the Black Series name.

    This special-edition Corsa tips our scales at an outlandish 5.338kg (size-medium). That’s with standard butyl inner tubes, as the bike was being studio shot when I came across it.

    Wallis claims the bike weighs in at 5.241kg in full tubeless trim.

    Frame and fork details

    Garbar UK cassette
    The Garbaruk cassette weighs only 275g for a 10-44. Warren Rossiter / OurMedia

    The frame is a single monocoque construction made with a complex dual-mould technology. The Corsa frames are all proportional, meaning the diameter of the tubing expands across the sizes. This is intended to ensure the ride is the same from XS to XL sizes.

    The geometry is aggressive, with a super-short back end with 405mm chainstays.

    The Corsa frame has generous tyre clearances (conservatively 36mm, although it looks greater than that) and a threaded T47 bottom bracket shell.

    Carbon disc rotors
    Even the 160/140mm disc rotors sit on carbon fibre carriers. Warren Rossiter / OurMedia

    The head angle is race-bike steep, and the front centre is longer than standard road bike geometry.

    Wallis tells me the idea behind the Corsa is to build a classic climber’s race bike, yet one that adds stability on descents with the longer front centre.

    Black Series carbon-one piece cockpit
    The carbon one-piece cockpit is available in a huge range of sizes and made to order. Warren Rossiter / OurMedia

    The frame and fork are light at 595.7g (unpainted, size medium) and 348g (300mm steerer), respectively. That’s impressive for a bike with internal routing and clearance for 36mm tyres. It gives current featherweight bikes such as Scott’s latest Addict RC (640g) and Specialized’s Aethos (585g, size 56cm) a run for their money.

    Attention to detail

    Black Seroes Corsa chainset and Carbon-Ti chainring
    The Black Series Corsa crankset, here fitted with a Carbon-Ti chainring, is one of the lightest you’ll find. Warren Rossiter / OurMedia

    This Black Series bike, however, cheats the scales further thanks to its build. The 220g (100mm x 42cm) one-piece bar/stem is made in collaboration with German lightweight specialist Schmolke. The internally routed one-piece design bonds the stem piece to the bar. That means the combination is available in any size you could wish for.

    The carbon crankset is also a collaboration, with carbon specialist THM, weighing 289g (172.5mm) with a Carbon-Ti chainring at 112g.

    Black Series Corsa front wheel
    The Black Series Corsa front wheel tips the scales at only 501g. Warren Rossiter / OurMedia

    Conventional wheels, unconventional weight

    Black Series Corsa rear wheel
    The rear wheel comes in at 580g. Warren Rossiter / OurMedia

    The Corsa wheels, which use a conventional 28-spoke build, connect the 280g rims via Sapim CX-Ray spokes, with Black Series’ own ultra-light hubset (64g front, 149g rear). The wheels weigh in at a mere 1,081g a pair, including tubeless rim tape.

    They’re shod with Tufo’s 220g Comtura Prima tubeless tyres in a rough-road ready 32mm width.

    Completing the build is a Corsa seatpost made in collaboration with THM and weighing 85g (27.2x350mm). It’s topped with a Black Series Corsa saddle at an astonishingly light 52g. The 27.2mm-diameter post is available as an inline or offset option.

    Black Series front through axle
    The Black Series front thru-axle weighs only 15g. Warren Rossiter / OurMedia

    As you might expect from a brand born out of Poshbikes’ history, the attention to detail goes further in the pursuit of weight reduction than you’ll see from perhaps any other brand.

    Take the Black Series Corsa thru-axles, for example.

    These are made from a moulded carbon shaft with a ceramic insert for the hex key slot. They are tipped with a metal-threaded end piece that’s keyed and bonded to the shaft. The weights for the road versions of these axles are an astonishing 17g (rear) and 15g (front).

    Black Series rear through axle
    The Black Series rear thru-axle weighs only 17g. Warren Rossiter / OurMedia
    Black Series carbon M5 x 15mm bottle cage bolts
    Four Black Series carbon M5 x 15mm bottle cage bolts weigh 2 grams. Warren Rossiter / OurMedia

    Even the bottle cage bolts are the lightest available. These carbon fibre bolts are sourced from the aeronautic industry. A set of four M5 x 15mm bolts weighs only 2g.

    43g carbon saddle
    The 52g carbon saddle is made in Italy by a carbon motorsport specialist. Warren Rossiter / OurMedia

    Availability and pricing

    Black Series Corsa
    The Black Series Corsa is a seriously lightweight bike. Warren Rossiter / OurMedia

    This ‘Ultimate’ SL build will be available from Black Series before the end of the year with an expected retail price of £16,000 / $21,650 / €18,350.

    Wallis told me he’s confident he could build an even lighter version of the bike at less than 5kg.

    Qualcomm Begins Posting Linux Patches For Snapdragon X2 Elite, 8 Elite Gen 5 SoCs

    Yesterday at the Snapdragon Summit in Hawaii Qualcomm announced the Snapdragon X2 Elite SoCs for upcoming laptops. In addition Qualcomm announced the Snapdragon 8 Elite Gen 5 mobile platform too. With those announcements out there, the Qualcomm open-source engineers have been busy in rolling out their latest patches for beginning to enable these new platforms with the Linux kernel…

    Gunman Contracts Highlights Action-Packed Gunplay In New Devlog

    Gunman Contracts – Stand Alone offered a fresh look at gunplay in a new action-packed devlog before this year’s PC VR launch.

    Gunman Contracts, a PC VR and flatscreen FPS, just released a devlog showing its latest update dubbed “The Gunman’s Base.” While the previous devlog was released almost a year ago, this new update sheds new light on your hub known as ‘The Hive.’ Earlier videos had shown carefully curated levels full of cutthroat enemies ready to gun you down, and this offers a closer look at target shooting and weapon customization.

    With an underground facility where you can choose, customize, and fire your weapons in a private shooting range, Gunman Contracts’ base is ready to welcome all trigger-happy players. This action movie-inspired shooter also hosts a target course with more dynamic on-the-move enemy pop-ups to hone your skills.

    A counter awaits at the end of each showdown to weigh up your accuracy, time, and total kills. This devlog also showcases the Combat Arena, pitting players against holo agents that look like real enemies, all of whom are willing to hunt you down.

    First taking shape as a Half-Life: Alyx mod, developer ANB_Seth is working on this shooter in partnership with publisher 2080 Games (MiRacle Pool). A Steam FAQ confirms the early access period is currently estimated to last “around 2-3 years,” aiming to include the first contract with “around 5-6” contracts for the full release.

    Gunman Contracts – Stand Alone targets a 2025 release on Steam Early Access.

    Qualcomm says its new Snapdragon chips are ‘the fastest and most efficient’ for Windows PCs

    Qualcomm has unveiled its new Snapdragon X Series chips for laptops, in addition to its new system-on-a-chip for flagship phones. The Snapdragon X2 Elite Extreme chip meant for “ultra-premium” Windows 11 laptops are designed to handle “complex, expert-level workloads” and to enable fast AI processing, as well as a multi-day battery life. Meanwhile, the Snapdragon X2 Elite chips come in two variants, one with 18 total cores and one with 12. Qualcomm claims that these processors are the “fastest, most powerful and efficient processors for Windows PCs.”

    The company launched the first Snapdragon X Elite chip in 2023 as its successor to the Snapdragon 8cx Gen 3 line of laptop processors. Qualcomm changed its name back then to reflect the huge leap in performance. Microsoft released a lineup of Copilot+ PCs with the new Snapdragon chip in 2024. And then earlier this year, at CES, Qualcomm unveiled the Snapdragon X for Copilot+ PCs priced $600 and under. 

    Qualcomm says that the new Elite Extreme chip can power laptops for scientists and professional creators who handle “computationally intense data analytics, professional media editing and scientific research.” It features the company’s third-gen Oryon CPU that can apparently run at up to 75 percent faster than competitors. The chip also comes equipped with Qualcomm’s Hexagon NPU, which it says is the “fastest NPU for laptops,” to enable simultaneous AI tools and experiences on Copilot+ PCs.

    The lower tier Elite chips can still run at up to 31 percent faster and use 43 percent less energy than the previous generation. While they’re obviously meant for users who don’t handle more resource-intensive workloads, Qualcomm says they also enable simultaneous AI experiences. The first laptops powered by the Snapdragon X2 Elite processors will be available in the first half of 2026. 

    This article originally appeared on Engadget at https://www.engadget.com/computing/qualcomm-says-its-new-snapdragon-chips-are-the-fastest-and-most-efficient-for-windows-pcs-084535090.html?src=rss

    Trump administration bars Giant Bicycles imports to the US, citing forced labour

    American customs officials will bar the import of bicycles manufactured in Taiwan by Giant Bicycles following an investigation that found evidence of forced labour.

    The US Customs and Border Protection (CBP) will detain bicycles, bicycle parts and accessories manufactured in Taiwan, effective immediately after issuing a Withhold Release Order. 

    CBP said it identified five ‘forced labour indicators’ during its investigation of Giant: abuse of vulnerability; abusive working and living conditions; debt bondage; withholding wages; and excessive overtime. 

    CBP said Giant, the largest bicycle manufacturer in the world, “profited by imposing such abuse”, resulting in goods produced below market value and thereby “undercutting American businesses by millions of dollars”.  

    Acting Executive Assistant Commissioner of CBP’s Office of Trade Susan S. Thomas said: “Importers have a responsibility to do their due diligence and know their supply chains. CBP will continue to investigate allegations of forced labor and take action when we find it in U.S. supply chains.”

    In a statement published on its website, the Giant Group said it is “firmly committed to upholding human rights and labor protections”.

    Giant said it has taken “concrete actions” in the last year: “Since January 2025, we have fully implemented a Zero Recruitment Fee Policy, under which all recruitment, agency, and government-related fees for newly hired migrant workers are fully covered by the company.

    “By the end of 2024, we completed upgrades to employee housing, providing a safer and more comfortable living environment.”

    Giant Group said it will file a petition to seek the revocation of the Withhold Release Order and explain to the CBP that the company has “already adopted appropriate measures”. 

    Giant said it expects some shipments to the US may experience delays and inspections in the short term. 

    “The Group will continually provide timely updates and maintain open communication with global stakeholders to foster a responsible and resilient industry environment,” the statement said.

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    Teaching Experience AI: Lessons from educators in Mexico

    In classrooms across Mexico, a transformation is unfolding. The Experience AI programme isn’t just teaching students about artificial intelligence, it’s empowering teachers and learners to explore, question, and create with it. By equipping educators with accessible tools and sparking curiosity among students, the initiative is shaping a new generation ready to use AI responsibly and creatively.

    Teacher at the front of the classroom

    Educators like Guadalupe Cortes, Lilia Violeta Garvia Sanchez, Ines Martinez, and Ana Judith Zavaleta are at the forefront of this shift. Their experiences reveal just how transformative Experience AI has become.

    From fear to fascination: Demystifying AI

    For many, AI can feel abstract, something from science fiction. Science and math teacher Lilia Violeta Garvia Sanchez remembers that both she and her students once viewed AI as “robots that would take over the world.” Fear gave way to fascination, however, once Experience AI entered the classroom.

    Through hands-on lessons, students quickly discovered AI as a practical tool rather than a threat. “I’ve seen a change in the students,” Lilia explains. “They were afraid at first, but now they’re curious and engaged.”

    Technology teacher Ines Martinez admits she was also surprised: “I thought the language would be more technical or complex, but it was pleasantly accessible — and very useful.”

    Equipping educators with tools that work

    A defining strength of Experience AI is its adaptability. Teachers can tailor materials to fit their classrooms while still leaning on the program’s robust foundation.

    Guadalupe Cortes points to the built-in glossary as a game-changer: “It was really helpful for me.” She values being able to choose what fits her teaching to keep it relevant: “I selected certain parts to connect with projects I was already running.”

    Sparking critical thinking and ethical awareness

    Experience AI pushes students to think deeply about the ethics and implications of AI.

    In Ines’s class, students raised concerns about water use in data centres and debated how to protect their digital identities. They weren’t just learning facts, they were making connections to real-world issues.

    Educator supporting young learner in the classroom

    Another teacher, Ileana Beurini, described an exercise where students asked different AI models the same political question. When answers varied, they discussed bias and the importance of consulting multiple sources. In another activity, searching images of “worker” led to a conversation about gender equity in technology.

    As Ines puts it: “They don’t want it to do all the thinking for them. They said it should be a support — a tool to generate better information, not to replace reasoning or reflection.”

    Transforming engagement and performance

    The impact on student motivation has been striking. For Ana Judith Zavaleta, the shift was clear: “They’re much more hands-on now — they don’t rely as much on textbooks or theory.” One student who typically struggled academically became one of the most enthusiastic participants, even passing where he previously failed.

    Guadalupe Cortes has seen similar enthusiasm: “They’re finding a real purpose in using AI for their own benefit.” At an entrepreneurship fair, her students applied AI concepts to improve their projects, proof that these lessons extend far beyond the classroom.

    A call to action for educators

    The teachers’ message is unanimous: embrace AI.

    “We should give it a try,” urges Lilia. “Just because we’re teachers doesn’t mean we have to know everything. The world is evolving every single day, and we need to innovate with our students so they feel motivated to keep learning.”

    Young learners work on the classroom wall

    For Ines, the takeaway is simple but powerful: “Take the risk — really, take the chance to learn. Just like the internet became essential, AI will become part of our daily lives and necessary for all areas of teaching — and life itself.”

    More than just a set of resources

    Experience AI is more than a set of resources, it’s a movement preparing students to navigate the future with curiosity, critical thinking, and ethical awareness. By igniting minds in Mexico, it’s helping to cultivate responsible digital citizens who will shape not just their classrooms, but the world beyond them.

    For more information about Experience AI, visit our website: rpf.io/experienceai

    For more information about our global Experience AI partner in Mexico, visit: educacionparacompartir.org

    The post Teaching Experience AI: Lessons from educators in Mexico appeared first on Raspberry Pi Foundation.

    Experimental Gene Therapy Found To Slow Huntington’s Disease Progression

    Doctors report the first successful treatment for Huntington’s disease using a new type of gene therapy given during 12 to 18 hours of delicate brain surgery. The BBC reports: An emotional research team became tearful as they described how data shows the disease was slowed by 75% in patients. It means the decline you would normally expect in one year would take four years after treatment, giving patients decades of “good quality life”, Prof Sarah Tabrizi told BBC News. The first symptoms of Huntington’s disease tend to appear in your 30s or 40s and is normally fatal within two decades — opening the possibility that earlier treatment could prevent symptoms from ever emerging. None of the patients who have been treated are being identified, but one was medically retired and has returned to work. Others in the trial are still walking despite being expected to need a wheelchair. Treatment is likely to be very expensive. However, this is a moment of real hope in a disease that hits people in their prime and devastates families. […]

    It starts with a safe virus that has been altered to contain a specially designed sequence of DNA. This is infused deep into the brain using real-time MRI scanning to guide a microcatheter to two brain regions – the caudate nucleus and the putamen. This takes 12 to 18 hours of neurosurgery. The virus then acts like a microscopic postman — delivering the new piece of DNA inside brain cells, where it becomes active. This turns the neurons into a factory for making the therapy to avert their own death. The cells produce a small fragment of genetic material (called microRNA) that is designed to intercept and disable the instructions (called messenger RNA) being sent from the cells’ DNA for building mutant huntingtin. This results in lower levels of mutant huntingtin in the brain. […]

    The data showed that three years after surgery there was an average 75% slowing of the disease based on a measure which combines cognition, motor function and the ability to manage in daily life. The data also shows the treatment is saving brain cells. Levels of neurofilaments in spinal fluid — a clear sign of brain cells dying — should have increased by a third if the disease continued to progress, but was actually lower than at the start of the trial.


    Read more of this story at Slashdot.