An anonymous reader shares a research paper: Researchers have developed a ‘deep learning’ computer program that produces blueprints for the sequences of reactions needed to create small organic molecules, such as drug compounds. The pathways that the tool suggests look just as good on paper as those devised by human chemists. The tool is not the first software to wield AI instead of human skill and intuition. Yet chemists hail the development as a milestone, saying that it could speed up the process of drug discovery and make organic chemistry more efficient. “What we have seen here is that this kind of artificial intelligence can capture this expert knowledge,” says Pablo Carbonell, who designs synthesis-predicting tools at the University of Manchester, UK, and was not involved in the work. He describes the effort as “a landmark paper.” […] Chemists have conventionally scoured lists of reactions recorded by others, and drawn on their own intuition to work out a step-by-step pathway to make a particular compound. They usually work backwards, starting with the molecule they want to create and then analysing which readily available reagents and sequences of reactions could be used to synthesize it — a process known as retrosynthesis, which can take hours or even days of planning. The new AI tool, developed by Marwin Segler, an organic chemist and artificial-intelligence researcher at the University of Munster in Germany, and his colleagues, uses deep-learning neural networks to imbibe essentially all known single-step organic-chemistry reactions — about 12.4 million of them. This enables it to predict the chemical reactions that can be used in any single step. The tool repeatedly applies these neural networks in planning a multi-step synthesis, deconstructing the desired molecule until it ends up with the available starting reagents.

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Source: Slashdot – AI Tool, Which Has Digested Nearly Every Reaction Ever Performed, Can Invent New Ways To Create Complex Molecules

An anonymous reader shares a report: In the town of Wilberforce, Ontario, a quick detour from the main street will take you to a seven-foot-tall wooden fork that sits at the point where the road splits into two — a literal fork in the road. Unfamiliar passers-by may think it’s a joke. But to locals, this landmark goes by the name “Fork and Beans.” It has a logbook hidden inside its frame and it’s one of the more than 500 geocaches scattered around Wilberforce — the “Geocaching Capital of Canada,” as the town calls itself, and home of one of the most popular geocaching tours in the world. The rise of Pokemon Go in 2016 brought with it a surge of location-based outdoor games on mobile. Geocaching, which is akin to an outdoor scavenger hunt, uses GPS to locate hidden caches with logbooks inside and predates the latest crop of augmented reality games; it was a fixture of internet culture at the turn of the millenium. Geocachers use either an app or a GPS-enabled device to search for hidden containers (usually filled with something like a notebook) that are nearby or that they’ve sought out online. According to Geocaching HQ, a company that created one of the largest websites for the geocaching community in 2000, there are currently more than three million of these caches hidden in more than 190 countries around the world. For Wilberforce, geocaching is more than a game from back when a low-res dancing baby was the height of online entertainment. It’s a growing industry, with new caches being hidden and special events organized every year, that is helping keep the town afloat amidst economic struggles.

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Source: Slashdot – A Struggling Town Is Reviving Itself With… Geocaching

Amazon announced last year that it intends to shut down its dedicated cloud music locker. Now, the company has elaborated on its thinking. From a report: In an email to Amazon Music users, the company says uploaded songs will be removed from a user’s library on April 30th, 2018. You can however keep any music in the cloud by proactively going to your Music Settings and clicking the “Keep my songs” button. Back in December, Amazon stopped letting users upload new tracks to Music Storage, which holds up to 250 songs for free. The company said at the time that by January 2019, users wouldn’t be able to download or stream tracks they’ve uploaded to Music Storage, so it sounds like you’ll still have many months between April and next January to get your music downloaded and onto a different storage platform or hard drive.

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Source: Slashdot – Amazon’s Music Storage Service Will Remove MP3 Files on April 30