“With new COVID variants and subvariants evolving faster and faster, each chipping away at the effectiveness of the leading vaccines, the hunt is on for a new kind of vaccine,” reports the Daily Beast, “one that works equally well on current and future forms of the novel coronavirus.

“Now researchers at the National Institutes of Health in Maryland think they’ve found a new approach to vaccine design that could lead them to a long-lasting jab. As a bonus, it also might work on other coronaviruses, not just the SARS-CoV-2 virus that causes COVID-19.”
The NIH team reported its findings in a peer-reviewed study that appeared in the journal Cell Host & Microbe earlier this month.

The key to the NIH’s potential vaccine design is a part of the virus called the “spine helix.” It’s a coil-shaped structure inside the spike protein, the part of the virus that helps it grab onto and infect our cells. Lots of current vaccines target the spike protein. But none of them specifically target the spine helix. And yet, there are good reasons to focus on that part of the pathogen. Whereas many regions of the spike protein tend to change a lot as the virus mutates, the spine helix doesn’t.

That gives scientists “hope that an antibody targeting this region will be more durable and broadly effective,” Joshua Tan, the lead scientist on the NIH team, told The Daily Beast….

A vaccine that binds the spine helix in SARS-CoV-2 should hold up for a long time. And it should also work on all the other coronaviruses that also include the spine helix — and there are dozens of them, including several such as SARS-CoV-1 and MERS that have already made the leap from animal populations and caused outbreaks in people….

Maybe a spine-helix jab is in our future. Or maybe not. Either way, it’s encouraging that scientists are making incremental progress toward a more universal coronavirus vaccine. One that could work for many years on a wide array of related viruses.

Read more of this story at Slashdot.

Source: Slashdot – Beyond Spike Proteins: Researchers Suggest New Design for Longer Lasting Covid Vaccines:

hardaker writes: I wrote up the results from studying graphs of CO2 measurement data during a trip I took from Sacramento, California to London to attend the IETF-115 conference. Since CO2 is considered to be a potential proxy for measuring exposure to airborne viruses, it provided me with a rough guess about how safe (or not) I was at various points of my travel.

TL;DR: big conference rooms: good, busses: bad, everything else: in between.

“Numbers alone do not effectively measure risk absolutely,” the page concludes. “You must combine numbers with logic and common sense. Airlines with good filtering systems are likely ok. But do aim the fans at you with maximum air flow…”

“Hallways and crowded coffee tables are where we need to worry the most. Unfortunately, the masking policy at IETF-115 was sort of backward: in the rooms the circulation was quite good, but in all my graphs you can see a spike as I wandered from one room to another, and this is where masking policies were more lax allowing participants to remove their masks.”

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Source: Slashdot – Measuring Virus Exposure Risk Using a CO2 Sensor While Traveling

He’s been a contributing editor at the Linux foundation’s Linux.com, a contributor to Linux Journal, and a blogger for Linux Pro magazine. Now Bruce Byfield has teamed with the lead editor for the Open Office authors volunteer group (who was also co-lead on Open Office’s documentation project) to co-author a second edition of Byfield’s book Designing with LibreOffice.

From the official announcement:

The book is available as an .ODT or .PDF file under the Creative Commons Attribution/Sharealike License version 4.0 or later from https://designingwithlibreoffice.com. [“Under this license, you can share or copy the book, or even add to it,” explains the book’s site, “so long as you mention the writer’s name and release your changes under the same license.”]

The first edition was published in 2016, and was downloaded over thirty-five thousand times. Michael Meeks, one of the co-founders of LibreOffice, described the first edition as “an outstanding contribution to help people bring the full power of LibreOffice into their document….”

The second edition updates the original, removing outdated information and adding updated screenshots and new information about topics such as Harfbuzz font shaping codes, export to EPUB formats for ereaders, the Zotero extension for bibliographies, and Angry Reviewer, a Grammarly-like extension for editing diction.

In the future, the writers plan to release other editions as necessary to keep Designing with LibreOffice current.

Thanks to long-time Slashdot reader nanday for sharing the news.

Read more of this story at Slashdot.

Source: Slashdot – Authors Offer Free Downloads for New Second Edition of ‘Designing with LibreOffice’ Book

In 1999, Slashdot editor Hemos said Greg Bear was “rightly recognized as a master of hard science fiction” (introducing a review of Bear’s then-new book, Nebula-winning book Darwin’s Radio). In 2011 Bear began writing the Forerunner Saga , a trilogy of books set 100,000 years before the events in the game Halo.

Today theGamer.com writes that Bear has passed away at age 71:
Bear’s family and fans are paying tribute to the legendary author, who had more than 50 sci-fi novels to his name. Many share fond memories of reading Bear’s work and meeting him at conventions, describing him as generous, welcoming, and brilliant. Fans are also sharing their favourite books from Bear in tribute, encouraging others to explore his works to celebrate his legacy.

Bear’s wife, Astrid Bear, confirmed the news of his passing in the early hours of Sunday. This was after she revealed that her husband has been placed on life support, with no chance of making a full recovery after the stroke.

More from File770.com:
Bear’s novels won Nebulas for Moving Mars (1995) and Darwin’s Radio. Three other works of short fiction won Nebulas, and two of those — “Blood Music” (1984) and “Tangents” (1987) — also won the Hugo….

Bear sold his first short story, “Destroyers”, to Famous Science Fiction at age 15, and along with high-school friends helped found San Diego Comic-Con.
He also published work as an artist at the beginning of his career, including illustrations for an early version of theÂStar Trek Concordance,Âand covers forÂGalaxyÂandÂF&SF. He was a founding member of the Association of Science Fiction Artists. He even created the cover for his novel, Psychlone…

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Source: Slashdot – Hard Science Fiction Master Greg Bear Dies at Age 71

“Last week’s collapse of the cryptocurrency exchange FTX is sending aftershocks through the scientific community,” writes Science magazine:

An undergraduate physics major at the Massachusetts Institute of Technology (MIT) who founded FTX and quickly became a billionaire, 30-year-old Sam Bankman-Fried began to back philanthropic organizations that supported a wide variety of science-related causes, most designed to improve human well-being. Now, with FTX in bankruptcy and under investigation for misuse of investors’ money, his formerly flush foundations are suddenly strapped for cash and much of that work is at risk. One foundation, the Future Fund, was just launched in February. But by the end of June, its officials reported awarding 262 grants and “investments” totaling $132 million.

It’s unclear how much of that money has been distributed. But on 10 November, five senior Future Fund officials resigned and announced in a statement, “We are devastated to say that it looks likely that there are many committed grants that the Future Fund will be unable to honor….”

Just what will happen to awards the Future Fund and the similar FTX Foundation have already made remains unclear. FTX owes billions of dollars to creditors and is now being investigated by the U.S. Securities and Exchange Commission and the Department of Justice, according to The Wall Street Journal. Writing in an online forum hosted by the Center for Effective Altruism, to which the Future Fund pledged nearly $14 million, Molly Kovite, legal operations manager for the Open Philanthropy foundation, noted that FTX’s creditors could try to “claw back” their investments during bankruptcy proceedings. If grantees received awards after 11 August, which is 90 days prior to the bankruptcy filing, “the bankruptcy process will probably ask you, at some point, to pay all or part of that money back” she predicts.

That has grantees wondering how they will pay the bills. “Everyone is obviously really worried,” Morrison says.
Thanks to Slashdot reader sciencehabit for submitting the article.

Read more of this story at Slashdot.

Source: Slashdot – Will FTX’s Collapse Strand Scientists?