An anonymous reader quotes a report from NPR: Carlene Knight’s vision was so bad that she couldn’t even maneuver around the call center where she works using her cane. But that’s changed as a result of volunteering for a landmark medical experiment. Her vision has improved enough for her to make out doorways, navigate hallways, spot objects and even see colors. Knight is one of seven patients with a rare eye disease who volunteered to let doctors modify their DNA by injecting the revolutionary gene-editing tool CRISPR directly into cells that are still in their bodies. Knight and [another volunteer in the experiment, Michael Kalberer] gave NPR exclusive interviews about their experience. This is the first time researchers worked with CRISPR this way. Earlier experiments had removed cells from patients’ bodies, edited them in the lab and then infused the modified cells back into the patients. […]

CRISPR is already showing promise for treating devastating blood disorders such as sickle cell disease and beta thalassemia. And doctors are trying to use it to treat cancer. But those experiments involve taking cells out of the body, editing them in the lab, and then infusing them back into patients. That’s impossible for diseases like [Leber congenital amaurosis, or LCA], because cells from the retina can’t be removed and then put back into the eye. So doctors genetically modified a harmless virus to ferry the CRISPR gene editor and infused billions of the modified viruses into the retinas of Knight’s left eye and Kalberer’s right eye, as well as one eye of five other patients. The procedure was done on only one eye just in case something went wrong. The doctors hope to treat the patients’ other eye after the research is complete. Once the CRISPR was inside the cells of the retinas, the hope was that it would cut out the genetic mutation causing the disease, restoring vision by reactivating the dormant cells.

The procedure didn’t work for all of the patients, who have been followed for between three and nine months. The reasons it didn’t work might have been because their dose was too low or perhaps because their vision was too damaged. But Kalberer, who got the lowest dose, and one volunteer who got a higher dose, began reporting improvement starting at about four to six weeks after the procedure. Knight and one other patient who received a higher dose improved enough to show improvement on a battery of tests that included navigating a maze. For two others, it’s too soon to tell. None of the patients have regained normal vision — far from it. But the improvements are already making a difference to patients, the researchers say. And no significant side effects have occurred. Many more patients will have to be treated and followed for much longer to make sure the treatment is safe and know just how much this might be helping.

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Source: Slashdot – CRISPR Gene-Editing Experiment Partly Restores Vision In Legally Blind Patients

Google Maps is getting a few new features to help people better understand our burning planet. Ars Technica reports: The first is a new “fire” layer in the main map view, which will let you view the exact boundaries of a wildfire just as easily as you can look up the current traffic patterns. Google has done fire information before as part of the “crisis response” website, but with climate change making “Fire Season” a yearly occurrence in dry areas like Australia and the Western U.S., wildfires will now be a top-level Maps feature.

Google says the new fire level will bring “all of Google’s wildfire information together” in an easy interface. In the US, it will also pull in data from the National Interagency Fire Center (NIFC), and the company says it wants to expand fire detail with other government agencies, starting with Australia in “the coming months.” Wildfire boundaries should be updated on an hourly basis, and Google says you’ll be able to tap on a fire to see information from local governments, like “emergency websites, phone numbers for help and information, and evacuation details. When available, you can also see important details about the fire, such as its containment, how many acres have burned, and when all this information was last reported.” The fire layout is rolling out to Android this week, with iOS and desktop coming in October.

Google also announced it’s going to expand the Tree Canopy tool it launched in 2020. This Google Maps tool combines Google’s plethora of aerial imagery with computer vision AI to generate a map that shows tree cover in cities. Today’s announced expansion will increase the Tree Canopy imagery from 15 cities to 100 cities worldwide. Google wants city planners to use the Tree Canopy tool to combat the phenomena of urban heat islands, where miles of asphalt and a dearth of shade from trees can cause cities to be significantly hotter than the surrounding areas. Google says heat islands “disproportionately impact lower-income communities and contribute to a number of public health concerns — from poor air quality to dehydration. With Tree Canopy data, local governments have free access to insights about where to plant trees to increase shade, reduce heat and mitigate these adverse effects.”

Read more of this story at Slashdot.

Source: Slashdot – Google Maps Tracks Global Warming With New ‘Fire’ Layer, Tree Canopy Tool

Ahmed Elgammal, Professor and Director of the Art & AI Lab at Rutgers University, writes via The Conversation: When Ludwig von Beethoven died in 1827, he was three years removed from the completion of his Ninth Symphony, a work heralded by many as his magnum opus. He had started work on his Tenth Symphony but, due to deteriorating health, wasn’t able to make much headway: All he left behind were some musical sketches. Ever since then, Beethoven fans and musicologists have puzzled and lamented over what could have been. His notes teased at some magnificent reward, albeit one that seemed forever out of reach. Now, thanks to the work of a team of music historians, musicologists, composers and computer scientists, Beethoven’s vision will come to life. I presided over the artificial intelligence side of the project, leading a group of scientists at the creative AI startup Playform AI that taught a machine both Beethoven’s entire body of work and his creative process. A full recording of Beethoven’s 10th Symphony is set to be released on Oct. 9, 2021, the same day as the world premiere performance scheduled to take place in Bonn, Germany — the culmination of a two-year-plus effort.
[…]
The AI side of the project — my side — found itself grappling with a range of challenging tasks. First, and most fundamentally, we needed to figure out how to take a short phrase, or even just a motif, and use it to develop a longer, more complicated musical structure, just as Beethoven would have done. For example, the machine had to learn how Beethoven constructed the Fifth Symphony out of a basic four-note motif. Four notes famously serve as the basis for Beethoven’s Fifth Symphony. Next, because the continuation of a phrase also needs to follow a certain musical form, whether it’s a scherzo, trio or fugue, the AI needed to learn Beethoven’s process for developing these forms. The to-do list grew: We had to teach the AI how to take a melodic line and harmonize it. The AI needed to learn how to bridge two sections of music together. And we realized the AI had to be able to compose a coda, which is a segment that brings a section of a piece of music to its conclusion. Finally, once we had a full composition, the AI was going to have to figure out how to orchestrate it, which involves assigning different instruments for different parts. And it had to pull off these tasks in the way Beethoven might do so.

In November 2019, the team met in person again — this time, in Bonn, at the Beethoven House Museum, where the composer was born and raised. This meeting was the litmus test for determining whether AI could complete this project. We printed musical scores that had been developed by AI and built off the sketches from Beethoven’s 10th. A pianist performed in a small concert hall in the museum before a group of journalists, music scholars and Beethoven experts. We challenged the audience to determine where Beethoven’s phrases ended and where the AI extrapolation began. They couldn’t. The success of these tests told us we were on the right track. But these were just a couple of minutes of music. There was still much more work to do. At every point, Beethoven’s genius loomed, challenging us to do better. As the project evolved, the AI did as well. Over the ensuing 18 months, we constructed and orchestrated two entire movements of more than 20 minutes apiece.

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Source: Slashdot – AI Completed Beethoven’s Unfinished Tenth Symphony

Security researchers have found a massive malware operation that has infected more than 10 million Android smartphones across more than 70 countries since at least November 2020 and is making millions of dollars for its operators on a monthly basis. The Record reports: Discovered by mobile security firm Zimperium, the new GriftHorse malware has been distributed via benign-looking apps uploaded on the official Google Play Store and on third-party Android app stores. If users install any of these malicious apps, GriftHorse starts peppering users with popups and notifications that offer various prizes and special offers. Users who tap on these notifications are redirected to an online page where they are asked to confirm their phone number in order to access the offer. But, in reality, users are subscribing themselves to premium SMS services that charge over $35 per month, money that are later redirected into the GriftHorse operators’ pockets.

Zimperium researchers Aazim Yaswant & Nipun Gupta, who have been tracking the GriftHorse malware for months, described it as “one of the most widespread campaigns the zLabs threat research team has witnessed in 2021.” Based on what they’ve seen until now, the researchers estimated that the GriftHorse gang is currently making between $1.5 million to $4 million per month from their scheme.

Read more of this story at Slashdot.

Source: Slashdot – New GriftHorse Malware Infects More Than 10 Million Android Phones