An anonymous reader shares a report: Microsoft is starting to roll out new changes to Windows Ink that let you write anywhere you can type in Windows 11. After months of previewing the changes, the handwriting-to-text conversion now works inside search boxes and other elements of Windows 11 where you’d normally type your input. […] If you have a Surface device with a stylus or any other Windows tablet that supports Windows Ink then you’ll immediately see this new feature if you head into Settings and start to write into a search box, or in other text edit fields in Windows 11.

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Source: Slashdot – Windows 11 Now Lets You Write Anywhere You Can Type

The US v. Google antitrust trial is about many things, but more than anything, it’s about the power of defaults. Even if it’s easy to switch browsers or platforms or search engines, the one that appears when you turn it on matters a lot. Google obviously agrees and has paid a staggering amount to make sure it is the default: testimony in the trial revealed that Google spent a total of $26.3 billion in 2021 to be the default search engine in multiple browsers, phones, and platforms. From a report: That number, the sum total of all of Google’s search distribution deals, came out during the Justice Department’s cross-examination of Google’s search head, Prabhakar Raghavan. It was made public after a debate earlier in the week between the two sides and Judge Amit Mehta over whether the figure should be redacted. Mehta has begun to push for more openness in the trial in general, and this was one of the most significant new pieces of information to be shared openly.

Just to put that $26.3 billion in context: Alphabet, Google’s parent company, announced in its recent earnings report that Google Search ad business brought in about $44 billion over the last three months and about $165 billion in the last year. Its entire ad business — which also includes YouTube ads — made a bit under $90 billion in profit. This is all back-of-the-napkin math, but essentially, Google is giving up about 16 percent of its search revenue and about 29 percent of its profit to those distribution deals.

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Source: Slashdot – Google Paid a Whopping .3 Billion in 2021 To Be Default Search Engine Everywhere

Antonio Regaladoarchive, reporting for MIT Technology Review: The gene-editing technology CRISPR has been used to change the genes of human babies, to modify animals, and to treat people with sickle-cell disease. Now scientists are attempting a new trick: using CRISPR to permanently cure people of HIV. In a remarkable experiment, a biotechnology company called Excision BioTherapeutics says it added the gene-editing tool to the bodies of three people living with HIV and commanded it to cut, and destroy, the virus wherever it is hiding. The early-stage study is a probing step toward the company’s eventual goal of curing HIV infection with a single intravenous dose of a gene-editing drug. Excision, which is based in San Francisco, says the first patient received treatment about a year ago.

This week, doctors involved in the study reported at a meeting in Brussels that the treatment appeared safe and did not have major side-effects. However, they withheld early data about the treatment’s effects, leaving outside experts guessing whether it had worked. “This is an exceptionally ambitious and important trial,” says Fyodor Urnov, a genome-editing expert at the University of California, Berkeley, who believes it “would be good to know sooner than later” what the effect was — “including, potentially, no effect.”

A failure wouldn’t come as a surprise to anyone familiar with HIV. It has proved a devious adversary: there is still no vaccine, even 40 years after the virus was identified in 1983. Still, pharmaceutical companies did develop antiretroviral drugs, which stop the virus from copying itself. Taking these pills lets people with HIV live normal lives. But if they stop, the virus will quickly rebound and, if left unchecked, cause the fatal syndrome of infections and cancers known as AIDS. One reason the virus can’t be fully wiped out with drugs alone is that it inserts its genetic material into the DNA of our cells, leaving behind hidden copies that can restart the infection.

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Source: Slashdot – Gene-Editing Trial on Three Individuals for HIV Cure Yields Uncertain Result