While scientists are still working to understand the effects an extended trip to space can have on the human body, research in recent years has suggested that astronauts may experience some pretty dramatic changes on both the physiological and psychological levels. In the latest study led by a team at University of California San Diego, researchers found signs of accelerated aging in human stem cells that spent roughly a month in space. 

The research focused on hematopoietic stem and progenitor cells (HSPCs), which are crucial in the formation of blood and immune cells. Stem cells were sent to the International Space Station for stays of 32-45 days using specially developed nanobioreactors to monitor them. Another set remained on Earth at the Kennedy Space Center. The cells that went to the ISS showed a host of changes, including reduced self-renewal abilities, greater susceptibility to DNA damage and inflammation in the mitochondria. However, the damage didn’t appear to be permanent. The team notes that the changes were at least partially reversed when the cells were removed from the space environment. 

“Space is the ultimate stress test for the human body,” Catriona Jamieson, director of the UC San Diego Sanford Stem Cell Institute, said in a statement. “These findings are critically important because they show that the stressors of space — like microgravity and cosmic galactic radiation — can accelerate the molecular aging of blood stem cells. Understanding these changes not only informs how we protect astronauts during long-duration missions but also helps us model human aging and diseases like cancer here on Earth.” 

This article originally appeared on Engadget at https://www.engadget.com/human-stem-cells-age-more-rapidly-in-space-study-finds-145651426.html?src=rss

Today, Porsche debuted a new 911 variant at the IAA Mobility show in Munich, Germany. It’s the most powerful 911 to date, excluding some limited-run models, and may well be the quickest to 60 mph from a standing start, dispatching that dash in just 2.4 seconds. And it’s all thanks to one of the most interesting hybrid powertrains on sale today.

Rather than just bolting an electric motor to an existing 911, Porsche designed an entirely new 3.6 L flat-six engine, taking the opportunity to ditch the belt drive and move some of the ancillaries, which can instead be powered by the car’s 400 V traction battery.

The system debuted in the 911 GTS T-Hybrid, which Ars recently reviewed. For that car, Porsche added a single electric turbocharger, which works like the MGU-H in a Formula 1 car. It spins up almost instantly to 120,000 rpm to eliminate throttle lag, but also recaptures excess energy from the spinning turbine and sends that to the 1.9 kWh battery pack.

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The Square Enix team behind Final Fantasy Tactics — The Ivalice Chronicles didn’t just remaster the iconic strategy RPG, they had to go through the trouble of remaking the source code from scratch, according to Bloomberg. In an interview with Bloomberg‘s Jason Schreier, the game’s director Kazutoyo Maehiro explained the arduous process of designing The Ivalice Chronicles, which is set to release at the end of the month.

When getting to work on the remake, Maehiro and his team discovered they had to rebuild the source code from the ground up since it was lost thanks to the industry’s unstandardized practices in the ’90s, according to Bloomberg. When translating Final Fantasy Tactics from Japanese to English for the global release, the company would overwrite the original Japanese version’s code. For Maehiro, that meant the team had to undertake a ground-up overhaul and recreate the source code by playing the original game that released in 1997, consulting the game’s master disc and looking at the 2011 version called Final Fantasy Tactics: The War of the Lions, according to Bloomberg. Maehiro also said during a PAX West 2025 panel that the team gleaned a lot of lost info from fan-made databases.

Revealing more of the behind-the-scenes decisions for The Ivalice Chronicles, Maehiro told Bloomberg about the debate surrounding Count Cidolfus Orlandeau. Better known as Cid, and appropriately nicknamed Thunder God Cid, this overtuned character joins you later in the game, but many fans complained about him being overpowered. Instead of nerfing Cid, Maehiro told Bloomberg that keeping this character’s power level the same would better represent the storyline since “his role in the story is being that very powerful character who joins your party.” To quell any concerns of Cid being too broken, Maehiro told Bloomberg that the team decided to buff the other characters to even things out. Looking ahead, Maehiro also hinted at exploring sequels for the Final Fantasy Tactics franchise or even brand new games in the strategy RPG genre, given that The Ivalice Chronicles does well, according to Bloomberg.

This article originally appeared on Engadget at https://www.engadget.com/gaming/the-ivalice-chronicles-team-had-to-remake-the-original-final-fantasy-tactics-source-code-from-scratch-190253342.html?src=rss