Your iPhone may soon be able to do more than call for emergency help and send messages via satellite, according to the latest Power On newsletter. Bloomberg‘s Mark Gurman reported that Apple is planning to expand on satellite features available on iPhones.
Apple introduced the ability to send and receive texts with the Messages via Satellite feature last year, but is reportedly looking to enhance this with the option to send photos too. Beyond texting, Apple wants to enable 5G NTN support on its iPhones, which allows cell towers to get a coverage boost by tapping into satellites, according to Gurman. For anyone who needs directions in a remote area without a cellular or Wi-Fi connection, Apple reportedly has plans to introduce satellite connectivity to Apple Maps.
Along with these upgrades, Gurman reported that Apple is looking into “natural usage” improvements where users won’t have to point their iPhones towards the sky to connect to a satellite network. Instead, an iPhone could stay connected even when there’s no clear view of the sky, like in indoor environments. On the developer side of things, Gurman said that Apple is also working on an API that allows app makers to add satellite connections.
There’s no timeline for when these rumored satellite features will go live, but Apple previously waited a couple of years between introducing Emergency SOS via Satellite in 2022 and Messages via Satellite with the release of iOS 18.
This article originally appeared on Engadget at https://www.engadget.com/mobile/smartphones/apple-is-reportedly-working-on-more-satellite-features-for-iphone-172151203.html?src=rss
Neurodiverse professionals may see unique benefits from artificial intelligence tools and agents, research suggests. With AI agent creation booming in 2025, people with conditions like ADHD, autism, dyslexia and more report a more level playing field in the workplace thanks to generative AI.
A recent study from the UK’s Department for Business and Trade found that neurodiverse workers were 25% more satisfied with AI assistants and were more likely to recommend the tool than neurotypical respondents.
[The study involved 1,000 users of Microsoft 365 Copilot from October through December of 2024.]
“Standing up and walking around during a meeting means that I’m not taking notes, but now AI can come in and synthesize the entire meeting into a transcript and pick out the top-level themes,” said Tara DeZao, senior director of product marketing at enterprise low-code platform provider Pega. DeZao, who was diagnosed with ADHD as an adult, has combination-type ADHD, which includes both inattentive symptoms (time management and executive function issues) and hyperactive symptoms (increased movement). “I’ve white-knuckled my way through the business world,” DeZao said. “But these tools help so much….”
Generative AI happens to be particularly adept at skills like communication, time management and executive functioning, creating a built-in benefit for neurodiverse workers who’ve previously had to find ways to fit in among a work culture not built with them in mind. Because of the skills that neurodiverse individuals can bring to the workplace — hyperfocus, creativity, empathy and niche expertise, just to name a few — some research suggests that organizations prioritizing inclusivity in this space generate nearly one-fifth higher revenue. “Investing in ethical guardrails, like those that protect and aid neurodivergent workers, is not just the right thing to do,” said Kristi Boyd, an AI specialist with the SAS data ethics practice. “It’s a smart way to make good on your organization’s AI investments.”
Apple’s AirPods 4 have dropped back down to a record low price in an early Black Friday deal on Amazon. If you aren’t looking for active noise cancellation, the model without ANC is a steal at 30 percent off, bringing it down to just $90 from its usual price of $130. The ANC version is on sale too, for anyone not on as tight a budget. AirPods 4 with active noise cancellation are going for $150 right now, down from $180.
The Apple AirPods 4 are the best budget AirPods you can get in 2025, with Apple’s H2 audio chip to support some of the more advanced audio features from more expensive models. They offer Voice Isolation, Personalized Spatial Audio with dynamic head tracking and more. If you get the model without active noise cancellation, you won’t have features like Transparency Mode and Conversation Awareness, or Apple’s hearing health tools. But, the entry-level model still offers great sound quality for the price.
This model also features the redesigned shape, which makes for a more comfortable and secure fit so you don’t have to worry about them falling out of your ears. A force sensor on the stem allows for basic touch controls, including play and pause, play next track, previous track and answer a call. You can also summon Siri by pressing and holding the stem. With the ANC version, you also have access to Live Translation, which can be initiated by pressing and holding the stem on both AirPods simultaneously.
You can expect to get up to 5 hours of battery life on a charge with the non-ANC model, and up to 30 hours using the USB-C charging case. On the other model with ANC active, that play time drops by about an hour.
Check out our coverage of the best Apple deals for more discounts, and follow @EngadgetDeals on X for the latest tech deals and buying advice.
This article originally appeared on Engadget at https://www.engadget.com/deals/black-friday-apple-deals-include-the-airpods-4-for-90-162917761.html?src=rss
UPDATE (11/9): America’s Federal Aviation Administration has now grounded all U.S. MD-11 and MD-11F aircrafts after Tuesday’s crash “because the agency has determined the unsafe condition is likely to exist or develop in other products of the same type design,” according to an emergency airworthiness directive obtained by CBS News.
American multinational freight company UPS had already “grounded its fleet of MD-11 aircraft,” reported the Guardian, “days after a cargo plane crash that killed at least 13 people in Kentucky. The grounded MD-11s are the same type of plane involved in Tuesday’s crash in Louisville. They were originally built by McDonnell Douglas until it was taken over by Boeing.”
More details from NBC News:
UPS said the move to temporarily ground its MD-11 fleet was made “out of an abundance of caution and in the interest of safety.” MD-11s make up 9% of the company’s air fleet, it said. “We made this decision proactively at the recommendation of the aircraft manufacturer. Nothing is more important to us than the safety of our employees and the communities we serve,” UPS spokesman Jim Mayer said… FedEx said early Saturday that it was also grounding its MD-11s. The UPS rival has 28 such planes in operation, out of a fleet of around 700, FedEx said.
Video shows that the left engine of the plane caught fire during takeoff and immediately detached, National Transportation Safety Board member Todd Inman said Wednesday. The National Transportation Safety Board is the lead agency in the investigation.
Thanks to long-time Slashdot reader echo123 for suggesting the article.
Budgeting can be a stressful, challenging and uncomfortable experience. While it’s completely possible to do it on your own, we’ve become fans of a few great budgeting apps. Take our favorite budgeting app Quicken, which is having a 50 percent off sale for Black Friday.
The Quicken Simplifi app is down to $3 monthly from $6 monthly, adding up to $36 for the year. Quicken Classic, the company’s “original desktop software” for “experienced investors” is also half off at $6 monthly, down from $12 monthly. The sale starts today and is available until Wednesday, December 3.
One of the many things that sets Quicken Simplifi apart from its competitors is its sleek, easy to use interface. The setup is pretty straightforward and it allows for your spouse or financial advisor to act as co-manager of the account.
It also clearly shows figures like net worth, recent spending, upcoming recurring payments and more. Plus, there’s an option to say if you’re expecting a refund. Quicken Simplifi unfortunately doesn’t offer a free trial so testing it out with a discount means less money invested if it’s not for you.
This article originally appeared on Engadget at https://www.engadget.com/deals/get-half-off-our-favorite-budgeting-app-for-black-friday-140025864.html?src=rss
CAPE CANAVERAL, Florida—The field of astrodynamics isn’t a magical discipline, but sometimes it seems trajectory analysts can pull a solution out of a hat.
That’s what it took to save NASA’s ESCAPADE mission from a lengthy delay, and possible cancellation, after its rocket wasn’t ready to send it toward Mars during its appointed launch window last year. ESCAPADE, short for Escape and Plasma Acceleration and Dynamics Explorers, consists of two identical spacecraft setting off for the red planet as soon as Sunday with a launch aboard Blue Origin’s massive New Glenn rocket.
“ESCAPADE is pursuing a very unusual trajectory in getting to Mars,” said Rob Lillis, the mission’s principal investigator from the University of California, Berkeley. “We’re launching outside the typical Hohmann transfer windows, which occur every 25 or 26 months. We are using a very flexible mission design approach where we go into a loiter orbit around Earth in order to sort of wait until Earth and Mars are lined up correctly in November of next year to go to Mars.”
A maintainer of Debian’s Advanced Package Tool (APT) “has announced plans to introduce hard Rust dependencies into APT starting May 2026,” reports the blog It’s FOSS.
The integration targets critical areas like parsing .deb, .ar, and tar files plus HTTP signature verification using Sequoia. [APT maintainer Julian Andres Klode] said these components “would strongly benefit from memory safe languages and a stronger approach to unit testing.”
He also gave a firm message to maintainers of Debian ports: “If you maintain a port without a working Rust toolchain, please ensure it has one within the next 6 months, or sunset the port.”
The reasoning is straightforward. Debian wants to move forward with modern tools rather than being held back by legacy architecture… Debian ports running on CPU architectures without Rust compiler support have six months to add proper toolchains. If they can’t meet this deadline, those ports will need to be discontinued. As a result, some obscure or legacy platforms may lose official support. For most users on mainstream architectures like x86_64 and ARM, nothing changes. Your APT will simply become more secure and reliable under the hood.
It’s FOSS argues that “If done right, this could significantly strengthen APT’s security and code quality.”
And the blog Linuxiac also supports the move. “By embedding Rust into APT, the distro joins a growing number of major open-source projects, such as the Linux kernel, Firefox, and systemd, that are gradually adopting Rust. And if I had to guess, I’d say this is just one of the first steps toward even deeper Rust integration in this legendary distribution, which is a good thing.”
You know what time it is, right? It’s time to shop early Black Friday deals with retailers getting a jump on the annual sale event. If it’s also time to get a new smartwatch, you’re in luck. The Apple Watch Series 10 is back down to an all-time low price. And remember those MacBook Air deals we highlighted a few days ago? Those are still available
Apple has continued its trend of giving users more creative freedom over how their iPhones look and feel, and one of the most striking new customization options in iOS 26 is the ability to stretch the clock on your lock screen. The feature, part of Apple’s refreshed design language for iPhone software, allows the time to expand across more of the screen, giving it a bold, modern appearance. Whether you prefer the minimalist look of small numerals or the dramatic impact of an oversized clock, iOS 26 makes it easy to adjust your lock screen style to suit your taste.
This new resizing option is officially referred to as “adaptive time,” and it transforms what used to be a static lock-screen element into something that feels more fluid and responsive. By dragging a simple on-screen handle, you can expand or shrink the size of the time display, creating a distinctive visual effect that gives your lock screen a fresh new personality.
How to stretch your lock-screen clock
To access the stretch option, start by waking your iPhone and remaining on the lock screen. Instead of unlocking the device, press and hold anywhere on the display to enter customization mode. This brings up a carousel of your saved lock screens, allowing you to edit the one that’s currently active. Tap “Customize,” then choose the “Lock Screen” option to enter the editor.
Once the editing screen appears, tap directly on the clock. This will bring up the familiar font and color panel introduced in earlier versions of iOS. To make the stretch feature available, the first font option (the default and leftmost style) must be selected. It should also be set to use the Arabic Western script. After confirming these settings, tap the clock again to close the font panel.
If the wallpaper supports the feature, a small circular drag handle will appear in the lower-right corner of the clock. Touch and hold this handle, then drag it downward to stretch the clock. The digits will expand in real time as you move your finger. When you’re happy with the size, release the handle. To save your changes, tap “Done” in the top-right corner of the screen. Exiting customization mode will reveal your new, enlarged clock on the lock screen.
If the stretch feature doesn’t appear, the issue is usually related to the font or wallpaper. Some wallpapers, particularly those with subjects that fill the upper portion of the frame, limit how much the clock can expand. If the image leaves little open space, iOS hides the handle to prevent the time from overlapping key parts of the photo. Switching to a simpler or more spacious wallpaper usually resolves this.
Understanding the stretched clock feature
In previous versions of iOS, the lock-screen clock was fixed in place. Regardless of the wallpaper used, its size and position remained the same. iOS 26 changes that by introducing a resize handle that appears on the bottom-right corner of the clock once the screen is in edit mode. When this handle is dragged downward, the digits expand, allowing the time to stretch dramatically toward the center of the screen. The feature works in both directions, meaning the clock can also be shrunk back to its previous size if the stretched look is too much for you.
The stretched clock effect works best with the new Liquid Glass interface design Apple introduced in iOS 26. This approach blends the clock’s font with the background, creating a subtle depth effect where the time appears to hover over the wallpaper. However, the resizing tool is not available on every setup. It only works when specific conditions are met, including the use of the default clock font and the standard Arabic Western script. If any other font or script is selected, the stretch handle will not appear.
Cherlynn Low for Engadget
Troubleshooting and limitations
The stretch function in iOS 26 is a visual adjustment, not a full-scale redesign of the lock screen, and there are a few limitations to be aware of. It works only with the default clock font, and changing the typeface or script will remove the resize option entirely. Users who rely on different numeral styles or custom fonts won’t see the handle appear. Similarly, widgets can interfere with resizing if they occupy too much space beneath the clock. Removing them temporarily can make it easier to adjust the clock size.
Some users have reported that the stretch handle disappears after software updates or when certain Focus modes are active. However, restarting your iPhone or disabling those modes typically restores it. As this is a relatively new feature, Apple may still be refining how it behaves across different iPhone models and lock-screen setups.
The visual impact of the stretched clock depends largely on your wallpaper. Minimal backgrounds with clean space at the top allow the time to expand without cluttering the screen. Complex or busy images tend to reduce the effect, as the clock will automatically adjust its transparency and positioning to stay readable. The stretched design looks particularly polished on wallpapers that match Apple’s new Liquid Glass aesthetic, where colors subtly blend through the numerals for a semi-transparent glow.
Making the most of your stretched clock
While the stretch feature is primarily cosmetic, it contributes to the broader trend of personalization across iOS. Apple’s lock-screen customization tools now include options for widgets, depth-aware wallpapers, color filters and dynamic animations, giving users more control than ever over their device’s appearance. The stretched clock fits naturally into this toolkit, offering an easy way to change the entire mood of your lock screen in seconds.
For users who prefer a bold, modern design, the larger clock size provides immediate impact and better visibility. Those who favor a more minimalist layout can keep it subtle by dragging the handle upward to restore the smaller, classic look. Whatever your preference, the process is reversible and quick, meaning you can experiment freely without losing your original layout.
Apple’s focus with iOS 26 is clearly on personalization and polish. The stretched clock may seem like a small detail, but it captures the overall philosophy behind this update, blending design flexibility with simple, intuitive gestures. With just a few taps and a short drag, your iPhone’s lock screen can transform into something uniquely yours, whether that’s a subtle enhancement or a bold statement across the display.
This article originally appeared on Engadget at https://www.engadget.com/mobile/smartphones/how-to-stretch-the-clock-on-your-lock-screen-in-ios-26-130032926.html?src=rss
After popular arcade games like Mortal Kombat and Spy Hunter, Midway Games jumped into the home console market, and in 2003 launched their baseball game franchise “MLB Slugfest” for Xbox, PS2, and GameCube. But at times it was almost a parody of baseball, including announcers filling the long hours of airtime with bizarre, rambling conversations. (“I read today that kitchen utensils are gonna hurt more people tonight than lifting heavy objects during the day…”)
Now former Midway Games producer Mark Flitman has revealed the even weirder conversations rejected by Major League Baseball. (“Ah, baseball on a sunny afternoon. Is there anything better? We’ve been talking about breaking pop bottles with rocks. I guess that is…”) The nonprofit Video Game History Foundation published the text in their digital archive — and shared 79 seconds of sound clips that were actually recorded but never used in the final game. (“Enjoying some smoked whale meat up here in the booth today…”)
Their BlueSky post with the audio drew over 5,500 likes and 2,400 reposts, with one commenter wondering if the bizarre (and unapproved) conversations were “part of the tactic where you include overtly inappropriate content to make the stuff you actually want to keep seem more appropriate.” But the Foundation’s library director thinks the voice actors were just going wild. “We talked with Mark on our podcast and it sounds like they just did a lot of improv and got carried away.” He added later that the game’s producer “would give them prompts and they’d run with it. The voice actors (Kevin Matthews and Tim Kitzrow) have backgrounds in sports radio and comedy, so they came up with wild nonsense like this.”
The gaming site Aftermath notes the Foundation also has an archive page for all the other sound files on the CD. Maybe it’s the ultimate tribute to the craziness that was MLB Slugfest. Years ago some fans of the game shared their memories on Reddit…
“The first time my friend tried to bean me and my hitter caught the ball was so hype, we were freaking out. Every game quickly evolved into trying to get our hitters to charge the mound.”
“I just remembered you could also kick the shit out of the fielder near your base if he got too close. Man that game was awesome.”
“You could do jump kicks into the catcher like Richie from The Benchwarmers.”
“Every time someone got on base we would run the ball over to them and beat their asses for 30 seconds. Good times.”
Six years after the launch of the franchise, Midway Games declared bankruptcy.
“For months, extremely personal and sensitive ChatGPT conversations have been leaking into an unexpected destination,” reports Ars Technica: the search-traffic tool for webmasters , Google Search Console.
Though it normally shows the short phrases or keywords typed into Google which led someone to their site, “starting this September, odd queries, sometimes more than 300 characters long, could also be found” in Google Search Console. And the chats “appeared to be from unwitting people prompting a chatbot to help solve relationship or business problems, who likely expected those conversations would remain private.” Jason Packer, owner of analytics consulting firm Quantable, flagged the issue in a detailed blog post last month, telling Ars Technica he’d seen 200 odd queries — including “some pretty crazy ones.” (Web optimization consultant Slobodan ManiÄ helped Packer investigate…) Packer points out “nobody clicked share” or were given an option to prevent their chats from being exposed.
Packer suspected that these queries were connected to reporting from The Information in August that cited sources claiming OpenAI was scraping Google search results to power ChatGPT responses. Sources claimed that OpenAI was leaning on Google to answer prompts to ChatGPT seeking information about current events, like news or sports… “Did OpenAI go so fast that they didn’t consider the privacy implications of this, or did they just not care?” Packer posited in his blog… Clearly some of those searches relied on Google, Packer’s blog said, mistakenly sending to GSC “whatever” the user says in the prompt box… This means “that OpenAI is sharing any prompt that requires a Google Search with both Google and whoever is doing their scraping,” Packer alleged. “And then also with whoever’s site shows up in the search results! Yikes.”
To Packer, it appeared that “ALL ChatGPT prompts” that used Google Search risked being leaked during the past two months. OpenAI claimed only a small number of queries were leaked but declined to provide a more precise estimate. So, it remains unclear how many of the 700 million people who use ChatGPT each week had prompts routed to Google Search Console.
“Perhaps most troubling to some users — whose identities are not linked in chats unless their prompts perhaps share identifying information — there does not seem to be any way to remove the leaked chats from Google Search Console..”
The new series from Breaking Bad creator Vince Gilligan, Pluribus, was emphatically made by humans, not AI, reports TechCrunch:
If you watched all the way to the end of the new Apple TV show “Pluribus,” you may have noticed an unusual disclaimer in the credits: “This show was made by humans.” That terse message — placed right below a note that “animal wranglers were on set to ensure animal safety” — could potentially provide a model for other filmmakers seeking to highlight that their work was made without the use of generative AI.
In fact, yesterday the former X-Files writer told Variety “I hate AI. AI is the world’s most expensive and energy-intensive plagiarism machine….”
He goes on, about how AI-generated content is “like a cow chewing its cud — an endlessly regurgitated loop of nonsense,” and how the U.S. will fail to regulate the technology because of an arms race with China. He works himself up until he’s laughing again, proclaiming: “Thank you, Silicon Valley! Yet again, you’ve fucked up the world.”
He also says “there’s a very high possibility that this is all a bunch of horseshit,” according to the article. “It’s basically a bunch of centibillionaires whose greatest life goal is to become the world’s first trillionaires. I think they’re selling a bag of vapor.”
And earlier this week he told Polygon that he hasn’t used ChatGPT “because, as of yet, no one has held a shotgun to my head and made me do it.” (Adding “I will never use it.”)
Time magazine called Thursday’s two-episode premiere “bonkers.” Though ironically, that premiere hit its own dystopian glitch. “After months of buildup and an omnipresent advertising campaign, Apple’s much-anticipated new show Pluribus made its debut…” reports Macworld. “And the service promptly suffered a major outage across the U.S. and Canada.”
As reported by Bloomberg and others, users started to report that the service had crashed at around 10:30 p.m. ET, shortly after Apple made the first two episodes of the show available to stream. There were almost 13,000 reports on Downdetector before Apple acknowledged the problem on its System Status page. Reports say the outage was brief, lasting less than an hour…
[T]here remains a Resolved Outage note on Apple TV (simply saying “Some users were affected; users experienced a problem with Apple TV” between 10:29 and 11.38 p.m.), as well as on Apple Music and Apple Arcade, which also went down at the same time. Social media reports indicated that the outage was widespread.
“The Firefox brand is getting a refresh and you get the first look,” says a new web page at Firefox.com. “Kit’s our new mascot and your new companion through an internet that’s private, open and actually yours.”
Slashdot reader BrianFagioli believes the new mascot “is meant to communicate that message in a warmer, more relatable way.”
And Firefox is already selling shirts with Kit over the pocket (as well as stickers)…
For more than a decade, the nonprofit Common Crawl “has been scraping billions of webpages to build a massive archive of the internet,” notes the Atlantic, making it freely available for research.
“In recent years, however, this archive has been put to a controversial purpose: AI companies including OpenAI, Google, Anthropic, Nvidia, Meta, and Amazon have used it to train large language models.
“In the process, my reporting has found, Common Crawl has opened a back door for AI companies to train their models with paywalled articles from major news websites. And the foundation appears to be lying to publishers about this — as well as masking the actual contents of its archives…”
Common Crawl’s website states that it scrapes the internet for “freely available content” without “going behind any ‘paywalls.'” Yet the organization has taken articles from major news websites that people normally have to pay for — allowing AI companies to train their LLMs on high-quality journalism for free. Meanwhile, Common Crawl’s executive director, Rich Skrenta, has publicly made the case that AI models should be able to access anything on the internet. “The robots are people too,” he told me, and should therefore be allowed to “read the books” for free. Multiple news publishers have requested that Common Crawl remove their articles to prevent exactly this use. Common Crawl says it complies with these requests. But my research shows that it does not.
I’ve discovered that pages downloaded by Common Crawl have appeared in the training data of thousands of AI models. As Stefan Baack, a researcher formerly at Mozilla, has written, “Generative AI in its current form would probably not be possible without Common Crawl.” In 2020, OpenAI used Common Crawl’s archives to train GPT-3. OpenAI claimed that the program could generate “news articles which human evaluators have difficulty distinguishing from articles written by humans,” and in 2022, an iteration on that model, GPT-3.5, became the basis for ChatGPT, kicking off the ongoing generative-AI boom. Many different AI companies are now using publishers’ articles to train models that summarize and paraphrase the news, and are deploying those models in ways that steal readers from writers and publishers.
Common Crawl maintains that it is doing nothing wrong. I spoke with Skrenta twice while reporting this story. During the second conversation, I asked him about the foundation archiving news articles even after publishers have asked it to stop. Skrenta told me that these publishers are making a mistake by excluding themselves from “Search 2.0” — referring to the generative-AI products now widely being used to find information online — and said that, anyway, it is the publishers that made their work available in the first place. “You shouldn’t have put your content on the internet if you didn’t want it to be on the internet,” he said. Common Crawl doesn’t log in to the websites it scrapes, but its scraper is immune to some of the paywall mechanisms used by news publishers. For example, on many news websites, you can briefly see the full text of any article before your web browser executes the paywall code that checks whether you’re a subscriber and hides the content if you’re not. Common Crawl’s scraper never executes that code, so it gets the full articles.
Thus, by my estimate, the foundation’s archives contain millions of articles from news organizations around the world, including The Economist, the Los Angeles Times, The Wall Street Journal, The New York Times, The New Yorker, Harper’s, and The Atlantic…. A search for nytimes.com in any crawl from 2013 through 2022 shows a “no captures” result, when in fact there are articles from NYTimes.com in most of these crawls.
“In the past year, Common Crawl’s CCBot has become the scraper most widely blocked by the top 1,000 websites,” the article points out…
A CRISPR-based drug given to study participants by infusion is raising hopes for a much easier way to lower cholesterol, reports CNN:
With a snip of a gene, doctors may one day permanently lower dangerously high cholesterol, possibly removing the need for medication, according to a new pilot study published Saturday in the New England Journal of Medicine.
The study was extremely small — only 15 patients with severe disease — and was meant to test the safety of a new medication delivered by CRISPR-Cas9, a biological sort of scissor which cuts a targeted gene to modify or turn it on or off. Preliminary results, however, showed nearly a 50% reduction in low-density lipoprotein, or LDL, the “bad” cholesterol which plays a major role in heart disease — the No.1 killer of adults in the United States and worldwide. The study, which will be presented Saturday at the American Heart Association Scientific Sessions in New Orleans, also found an average 55% reduction in triglycerides, a different type of fat in the blood that is also linked to an increased risk of cardiovascular disease.
“We hope this is a permanent solution, where younger people with severe disease can undergo a ‘one and done’ gene therapy and have reduced LDL and triglycerides for the rest of their lives,” said senior study author Dr. Steven Nissen, chief academic officer of the Sydell and Arnold Miller Family Heart, Vascular & Thoracic Institute at Cleveland Clinic in Ohio…. Today, cardiologists want people with existing heart disease or those born with a predisposition for hard-to-control cholesterol to lower their LDL well below 100, which is the average in the US, said Dr. Pradeep Natarajan, director of preventive cardiology at Massachusetts General Hospital and associate professor of medicine at Harvard Medical School in Boston…
People with a nonfunctioning ANGPTL3 gene — which Natarajan says applies to about 1 in 250 people in the US — have lifelong levels of low LDL cholesterol and triglycerides without any apparent negative consequences. They also have exceedingly low or no risk for cardiovascular disease. “It’s a naturally occurring mutation that’s protective against cardiovascular disease,” said Nissen, who holds the Lewis and Patricia Dickey Chair in Cardiovascular Medicine at Cleveland Clinic. “And now that CRISPR is here, we have the ability to change other people’s genes so they too can have this protection.”
“Phase 2 clinical trials will begin soon, quickly followed by Phase 3 trials, which are designed to show the effect of the drug on a larger population, Nissen said.”
And CNN quotes Nissen as saying “We hope to do all this by the end of next year. We’re moving very fast because this is a huge unmet medical need — millions of people have these disorders and many of them are not on treatment or have stopped treatment for whatever reason.”
A former Business Analyst reportedly filed a class action lawsuit claiming that for years, hundreds of remote employees at Bank of America first had to boot up complex computer systems before their paid work began, reports Human Resources Director magazine:
Tava Martin, who worked both remotely and at the company’s Jacksonville facility, says the financial institution required her and fellow hourly workers to log into multiple security systems, download spreadsheets, and connect to virtual private networks — all before the clock started ticking on their workday. The process wasn’t quick. According to the filing in the United States District Court for the Western District of North Carolina, employees needed 15 to 30 minutes each morning just to get their systems running. When technical problems occurred, it took even longer…
Workers turned on their computers, waited for Windows to load, grabbed their cell phones to request a security token for the company’s VPN, waited for that token to arrive, logged into the network, opened required web applications with separate passwords, and downloaded the Excel files they needed for the day. Only then could they start taking calls from business customers about regulatory reporting requirements…
The unpaid work didn’t stop at startup. During unpaid lunch breaks, many systems would automatically disconnect or otherwise lose connection, forcing employees to repeat portions of the login process — approximately three to five minutes of uncompensated time on most days, sometimes longer when a complete reboot was required. After shifts ended, workers had to log out of all programs and shut down their computers securely, adding another two to three minutes.
Thanks to Slashdot reader Joe_Dragon for sharing the article.
Blue Origin stands ready to help NASA achieve its goals with regard to landing humans on the Moon as soon as possible, the company’s chief executive said Saturday in an interview with Ars.
“We just want to help the US get to the Moon,” said Dave Limp, CEO of the space company founded by Jeff Bezos. “If NASA wants to go quicker, we would move heaven and Earth, pun intended, to try to get to the Moon sooner. And I think we have some good ideas.”
Limp spoke on Saturday, about 24 hours ahead of the company’s second launch of the large New Glenn rocket. Carrying the ESCAPADE spacecraft for NASA, the mission has a launch window that opens at 2:45 pm ET (19:45 UTC) at Cape Canaveral Space Force Station in Florida, and runs for a little more than two hours.
The Associated Press reports that “For the past decade, Dr. Priscilla Chan and her husband Mark Zuckerberg have focused part of their philanthropy on a lofty goal — ‘to cure, prevent or manage all disease’ — if not in their lifetime, then in their children’s.”
During that decade they also funded other initiatives (including underprivileged schools and immigration reform), according to the article. But there’s a change coming:
Now, the billionaire couple is shifting the bulk of their philanthropic resources to Biohub, the pair’s science organization, and focusing on using artificial intelligence to accelerate scientific discovery. The idea is to develop virtual, AI-based cell models to understand how they work in the human body, study inflammation and use AI to “harness the immune system” for disease detection, prevention and treatment. “I feel like the science work that we’ve done, the Biohub model in particular, has been the most impactful thing that we have done. So we want to really double down on that. Biohub is going to be the main focus of our philanthropy going forward,” Zuckerberg said Wednesday evening at an event at the Biohub Imaging Institute in Redwood City, California…. Chan and Zuckerberg have pledged 99% of their lifetime wealth — from shares of Meta Platforms, where Zuckerberg is CEO — toward these efforts…
On Thursday, Chan and Zuckerberg also announced that Biohub has hired the team at EvolutionaryScale, an AI research lab that has created large-scale AI systems for the life sciences…
Biohub’s ambition for the next years and decades is to create virtual cell systems that would not have been possible without recent advances in AI. Similar to how large language models learn from vast databases of digital books, online writings and other media, its researchers and scientists are working toward building virtual systems that serve as digital representations of human physiology on all levels, such as molecular, cellular or genome. As it is open source — free and publicly available — scientists can then conduct virtual experiments on a scale not possible in physical laboratories.
“We will continue the model we’ve pioneered of bringing together scientists and engineers in our own state-of-the-art labs to build tools that advance the field,” according to Thursday’s blog post. “We’ll then use those tools to generate new data sets for training new biological AI models to create virtual cells and immune systems and engineer our cells to detect and treat disease….
“We have also established the first large-scale GPU cluster for biological research, as well as the largest datasets around human cell types. This collection of resources does not exist anywhere else.”
Store pages on Steam are looking a lot less cramped thanks to a new update. Pages have been made wider, with support for higher resolution images and new viewing modes for trailers and screenshots. You’ll notice changes in the top carousel and in the “About the Game” section, where some new formatting options should make things look a bit more organized. The update just rolled out to the public after first being tested among beta users.
With this update, pages have been widened to 1200 pixels, which Valve says “felt like a good balance where we can show more content on screen without overwhelming the page and making it hard to navigate.” There’s now the option of a large pop-up view called theater mode in the carousel, as well as full-screen mode. In addition to games’ store pages, Valve has slightly tweaked the appearance of search results and recommendation pages to be wider, and made store hubs, Steam Charts and the News Hub look more uniform.
You may also notice some more colorful backgrounds on games’ store pages and in bundle detail pages. Where you won’t see changes yet, though, is the homepage. While Valve says it’s working on “similar adjustments” for the homepage, those aren’t rolling out with this update.
This article originally appeared on Engadget at https://www.engadget.com/gaming/pc/steam-store-pages-get-a-mini-makeover-to-better-suit-wide-screens-200142506.html?src=rss
Long-time Slashdot reader AmiMoJo shared this report from Marine Insight:
The world’s largest cargo sailboat, Neoliner Origin, completed its first transatlantic voyage on 30 October despite damage to one of its sails during the journey. The 136-metre-long vessel had to rely partly on its auxiliary motor and its remaining sail after the aft sail was damaged in a storm shortly after departure… Neoline, the company behind the project, said the damage reduced the vessel’s ability to perform fully on wind power…
The Neoliner Origin is designed to reduce greenhouse gas emissions by 80 to 90 percent compared to conventional diesel-powered cargo ships. According to the United Nations Conference on Trade and Development (UNCTAD), global shipping produces about 3 percent of worldwide greenhouse gas emissions…
The ship can carry up to 5,300 tonnes of cargo, including containers, vehicles, machinery, and specialised goods. It arrived in Baltimore carrying Renault vehicles, French liqueurs, machinery, and other products. The Neoliner Origin is scheduled to make monthly voyages between Europe and North America, maintaining a commercial cruising speed of around 11 knots.
