Kia’s concept EVs often get more than the usual amount of attention because it tends to incorporate a lot of the ideas in the final production models — with the EV9 electric SUV being a good example of that. With that in mind, the company just unveiled the Concept EV3 and Concept EV4 representing its “Opposites Unite” design philosophy, with an emphasis on interior vibes, geometric shapes and sustainable materials. 

The smallish crossover Concept EV3 looks more production-ready, and Kia says it “offers the technology, practicality and design of [our] flagship SUV, the EV9.” That may be true, but the EV3 carries a bold, futuristic design as well. Like the EV9 concept, it has distinct geometric patterns including octagonal wheel wells that flare out considerably from the body, and echoes those shapes in the side skirts and taillights. 

The windshield is pushed forward to open up interior space, while the glass roofline slopes front to back and appears to float thanks to the disconnected C pillar. “The unexpected treatment of volumes and graphics simultaneously interlock with each other, creating a logical yet emotional design,” the company added in some top-tier concept car PR fluff. 

The interior is more fanciful, with a nearly button-free layout designed to emphasize the voluminous interior and create a “transformative cabin ambience,” Kia said. It features a horizontal screen mounted on top that functions as both gauge cluster and infotainment system, along with an oval steering wheel and real mirrors. The wide center console “table” converts to four modes, including “focus, social, refreshing and storage.” Meanwhile, the fiber weave materials and bioplastics make the cabin inviting and modern.

The Concept EV4 is a clean-sheet design with an emphasis on sportiness that also uses some strong geometric shapes. To that end, it has a low nose and long-tail silhouette with a wide stance, along with a “technical roof spoiler” — two small extensions on either side of the roof. Again, we’re seeing bulgy fenders, lots of bold lines and creases, a sloping glass roof and geometric lighting front and back. 

The interior is broadly the same as the Concept EV3, but an “HVAC user interface incorporates a control panel that can be neatly stored in the center console when not in use,” according to Kia. It incorporates handwoven fabrics in the vehicle’s storage area and dashboard to create a 3D effect, and features natural dies and recycled cotton in the interior. 

Kia didn’t get into the power, battery or other powertrain features of either car, and painted both as test cases to see what people think. “That’s why we came to Los Angeles and America’s savviest EV consumers, to gauge reaction to two potential opportunities within the Kia lineup,” said Kia America’s COO Steven Center. It looks like Kia has nailed these designs once again, so don’t be surprised to see them appear in some form as real production vehicles. 

This article originally appeared on Engadget at https://www.engadget.com/kias-latest-ev-concepts-go-big-on-geometrics-and-cabin-vibes-190529735.html?src=rss

Source: Engadget – Kia’s latest EV concepts go big on geometrics and cabin vibes

In a landmark decision, the UK’s Medicines and Healthcare products Agency (MHRA) approved the use of a gene-editing therapy called Casgevy for patients with sickle cell disease and beta thalassemia — both of which are hereditary disorders related to genetic mutations of the red blood cells. The treatment, manufactured by Vertex, is the first-ever approved therapy that utilizes CRISPR-based gene editing technology to treat eligible patients.

The UK approval of the novel therapy is informed by two previous global clinical trials that indicated the treatment’s efficacy. 97 percent of patients using Casgevy were relieved of severe pain associated with the blood disorders for at least 12 months after treatment during the trials. The results suggest that the gene editing treatment could replace the current standard for care. Stem cell therapy and bone marrow transplants are currently the only pathways to cure sickle cell disease and beta thalassemia, however, they involve a lot of risks.

Both sickle cell disease and beta thalassemia are blood disorders characterized by defective red blood cells that can’t carry oxygen, and require patients to get monthly blood transfusions that can be costly and time-consuming. Casgevy works by specifically targeting the genes in the bone marrow stem cells that produce faulty blood cells. For the treatment to work, a patient’s stem cells need to be extracted from their bone marrow, edited in a lab and then re-infused into the patient.

Despite its promising outlook, CRISPR-based therapies may not be easily available to the general public. Gene editing is an expensive endeavor. The Innovative Genomics Institute (IGI) estimates that the average CRISPR-based therapy will cost between $500,000 and $2 million per patient. The IGI has built out an ‘Affordability Task Force’ to tackle the issue of expanding access to these novel therapies.

Aside from costliness, gene editing therapies offer huge promise to innovate treatment pathways for rare conditions including neurodegenerative diseases, cancer and muscular atrophy. More importantly, this landmark approval for Casgevy “opens the door for further applications of CRISPR therapies in the future,” Prof Dame Kay Davies, a scientist from the University of Oxford, said. And new iterations of gene editing technologies may even surpass CRISPR in the future.

Casgevy is still being reviewed by regulatory agencies for safety standards in other countries, including the United States and Saudi Arabia. A marketing application, the first step towards approval for the therapy, was recently validated by the European Medicines Agency.

This article originally appeared on Engadget at https://www.engadget.com/uk-authorizes-first-gene-therapy-for-treating-sickle-cell-disease-184130989.html?src=rss

Source: Engadget – UK authorizes first gene therapy for treating sickle cell disease

The green bubble-blue bubble divide may be getting smaller soon. 9to5Mac is reporting that Apple has confirmed it will support the RCS messaging standard that it’s long eschewed. That’s not to say that messages from Android devices will no longer appear green on Apple’s iMessage app. It does mean that texts from iPhones to non-iOS devices will support the newer Rich Communication Services protocol, meaning they will not have to go through the aging SMS (and MMS) system. In the statement provided, Apple said “We believe RCS Universal Profile will offer a better interoperability experience when compared to SMS or MMS.”

That support will “work alongside iMessage, which will continue to be the best and most secure messaging experience for Apple users.” With new features like voice memo transcriptions and check-in that aren’t available on RCS, iMessage could still outshine default text messaging apps on Android. It also means there might not be change to any of the colors of the conversation bubbles.

Google has long taken potshots at Apple for not supporting RCS, saying the texting experience between iPhones and non-iPhones is so outdated it might as well be using a pager. With RCS support, messages between Android and iOS devices will be more secure (than over SMS), while media can be shared at higher quality.

This is a developing story. Please check back for updates.

This article originally appeared on Engadget at https://www.engadget.com/apple-will-start-supporting-rcs-in-2024-182232923.html?src=rss

Source: Engadget – Apple will start supporting RCS in 2024

If you’ve been wanting to splurge on a classic-ish synthesizer this holiday season, now just might be your time to shine. Reverb’s offering a massive discount on 2021’s Korg ARP 2600 M recreation. This deal brings the price down to $1,150 instead of $2,000, a savings of $850 or 42 percent. It’s worth noting that this sale is for brand-new models and not refurbished synthesizers, further sweetening the deal.

Korg’s ARP 2600 M reissue was 39 years in the making, as it recreates a synthesizer that stopped production all the way back in 1981, which is before E.T. even came out. This is a relatively faithful remake, though it’s much smaller and lighter than the original, which accounts for the “M” (mini) moniker.

You still get those three iconic oscillators and a dual-mode, self-oscillating low-pass filter that lets you peruse different sounds drawing from ARP’s storied history. There’s even a true spring reverb tank included and a pair of built-in speakers, which are great for hashing out ideas but shouldn’t be used for microphone recordings. For laying down tracks, use one of the TS style jacks, as this model lacks XLR audio outs.

It’s worth re-emphasizing how much the miniaturized and lightweight form factor streamlines the music-making process, despite the lack of a dedicated keyboard. This thing is half the size of the original and weighs just 13 pounds, making it easy to gig with or to move between studios. As a reference, the original ARP 2600 weighed nearly three times that. Also, snagging an original 1970s model can set you back as much as $13,000.

Microsoft’s AI ambitions are moving a bit backwards: Today, the company has confirmed that it’s bringing Copilot AI to Windows 10. At first, it’ll be available to Windows Insider users in an upcoming Release Preview update, where Copilot will appear on the right side of the Task Bar. Once selected, you’ll see the familiar Copilot interface, which you can use to ask the AI questions, manage Windows features or interact with documents. Microsoft says the Copilot window won’t overlap with desktop content or block open windows.

If this all sounds familiar, it’s because Windows Central reported that Windows 10 would be getting Copilot earlier this month. The move isn’t exactly surprising. While Windows 11 is Microsoft’s latest OS, it only accounts for 26 percent of Windows installations, according to GlobalStats. Windows 10, meanwhile, still holds 69 percent of the Windows market.

In 2020, Microsoft announced that Windows 10 reached 1 billion devices, and it still appears to be above that figure. Windows Central’s reporting suggests that Windows 11 is on 400 million devices, in comparison. Just one look at those numbers and it makes sense why Microsoft is bringing its latest tech into an aging OS (its “end of service” date is still October 14, 2025). If the company was able to declare it brought Copilot’s AI to 1.4 billion devices in 2023, this year of over-accelerated AI hype will have been worth it.

Windows 10’s Copilot will be previewed in North America, as well as parts of Asia and South America over the next few months. For Windows Insiders who want to get in line for the update, Microsoft suggests installing today’s November preview update. Additionally, they’ll need to enable the “Get the latest updates as soon as they’re available” feature in Windows Update.

This article originally appeared on Engadget at https://www.engadget.com/microsofts-copilot-ai-is-officially-coming-to-windows-10-180020032.html?src=rss

Source: Engadget – Microsoft’s Copilot AI is officially coming to Windows 10

Amazon is selling the diminutive Echo Dot smart speaker for just $23 as part of an early Black Friday deal. That’s a record low price for the gadget and represents a savings of more than 50 percent, as it typically costs $50. This deal is for the latest and greatest Echo Dot, and not a model from several generations ago.

The sale applies to various colorways, like gray, blue and black. The Echo Dot may be small in stature, but there’s a reason it made our list of the best smart speakers in 2023. This thing is actually pretty useful. The sound quality won’t blow you away when compared to its larger siblings, but the speaker gets plenty loud. It also features a temperature sensor and built-in Eero capabilities.

The globe-shape is pleasing, the colors are on point and set-up is simple, thanks to the affiliated Echo app. We liked this smart speaker at $50, so we certainly like it at $23. If you’ve been wanting to experiment with Alexa but were waiting for a good deal, this is it. If you buy this speaker, make sure to ask Alexa to sing the song about cats. Trust me.

Amazon’s sale extends beyond the company’s tiniest smart speaker. You can also nab the standard full-sized Echo speaker for $55, which represents a savings of $45. Additionally, the Echo Dot with Clock is on sale for $35 instead of $60. As the name suggests, this is the above Echo Dot, but with an LED clock. If you don’t want to spring for this version, you can always just ask Alexa to tell you the time.

Your Black Friday Shopping Guide: See all of Yahoo’s Black Friday coverage, here. Follow Engadget for Black Friday tech deals. Learn about Black Friday trends on In The Know. Hear from Autoblog’s experts on the best Black Friday deals for your car, garage, and home, and find Black Friday sales to shop on AOL, handpicked just for you.

This article originally appeared on Engadget at https://www.engadget.com/the-echo-dot-drops-to-a-record-low-of-23-in-an-amazon-black-friday-deal-174541440.html?src=rss

Source: Engadget – The Echo Dot drops to a record low of in an Amazon Black Friday deal