There have been some rumblings in recent months about USB connectivity problems with AMD Ryzen processors hooked up to 500 series motherboards. To be more specific, the problem seems to stem from USB 2.0 ports that go wonky when PCIe 4.0 is enabled on the motherboard. Given that many enthusiasts are rocking new GPUs like the Radeon RX 6800

Source: Hot Hardware – AMD Investigates USB Flakiness With PCIe 4 And 500 Series Chipsets, Here Are Possible Fixes