Looks like they might not be taking the blue pill after all. According to John Wick: Chapter 3 – Parabellum director and The Matrix stunt performer Chad Stahelski, Lilly and Lana Wachowski are indeed returning to their groundbreaking franchise to work on a new Matrix project.
Source: io9 – The Wachowskis Are Plugging Back Into The Matrix, According to John Wick’s Director