In the past, Alien: Isolation had been demoed with a VR mode running on the second Rift development kit (DK2), but unfortunately, the developers never did translate that over for the finalized version of the headset. One fan has taken matters into his own hands by designing a mod that lets you experience Isolation in VR with a Rift, though release notes suggest that it could be a recipe for nausea if you go about it the wrong way.
An alpha version of the so-called “MotherVR” mod has been released, adding Rift support to Alien: Isolation. The creator, Zack Fannon, who goes by the alias Nibre, plans to continue developing the mod to add additional features (including Vive support), but says he wanted to launch the mod in its early state so that people could start playing sooner rather than later. For now he warns the game is designed for seated play only, and works with an Xbox gamepad or keyboard and mouse. In the future, Fannon tells me that he hopes to add support for VR controllers like Touch.
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Source: [H]ardOCP – Mod Makes “Alien: Isolation” VR Mode Compatible with Oculus Rift